Phenotype Image Detail

Image

Caption

Paint-filled inner ears of wild-type (Zeb1^+/+), Zeb1^tm2Yhi/Zeb1⁺ (Zeb1^deltaEx1/+), Zeb1^tm2Yhi/Zeb1^tm2Yhi (Zeb1^{deltaEx1/deltaEx1}) and Zeb1^tm2Yhi/Zeb1^Tw (Zeb1^deltaEx1/Tw) mice at E14.5 are shown from lateral (A-D), medial (E-H), ventral (I-L) and dorsal (M-P) views. Inner ears from wild-type and Zeb1^tm2Yhi/Zeb1⁺ mice appeared similar and normal. Zeb1^tm2Yhi/Zeb1^tm2Yhi lateral semicircular canals had a subtle constriction (indicated by *) of the midportion of the canal that differed from those observed in Zeb1^Tw/Zeb1⁺ mice. The lateral semicircular canals of Zeb1^tm2Yhi/Zeb1^Tw mice did not contain this abnormality and resemble those of Zeb1^Tw/Zeb1⁺ mice. Zeb1^tm2Yhi/Zeb1⁺ mice have normal ABR thresholds (Q). a, anterior semicircular canal; c, cochlear duct; es, endolymphatic sac; l, lateral semicircular canal; p, posterior semicircular canal; s, saccule; u, utricle.

Copyright

This image is from Kurima K, PLoS Genet 2011 Sep;7(9):e1002307, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:177274

Associated Alleles

Symbol	Name
Zeb1^tm2Yhi	zinc finger E-box binding homeobox 1; targeted mutation 2, Yujiro Higashi
Zeb1^Tw	zinc finger E-box binding homeobox 1; twirler

Associated Genotypes

Allelic Composition	Genetic Background
Zeb1^tm2Yhi/Zeb1^tm2Yhi	B6.129-Zeb1^tm2Yhi
Zeb1^tm2Yhi/Zeb1^Tw	B6.Cg-Zeb1^tm2Yhi/Zeb1^Tw