Phenotype Image Detail

Image

Caption

Histology of various tissues from wild-type and Npc1^tm1Mbjg/Npc1^tm1Mbjg mice. Tissues from 9-week-old female wild-type (WT) (A-C) and Npc1^tm1Mbjg/Npc1^tm1Mbjg (npc1^pf/pf) (D-F) littermates were fixed, sectioned, and stained with H&E as described in Materials and Methods. Arrows (A) denote Purkinje cells that are present in cerebellum of WT mice but absent from mutant mice (Scale bars, 50 um; magnification: 40x).

Copyright

This image is from Xie X, Proc Natl Acad Sci U S A 2011 Sep 13;108(37):15330-5. Copyright 2011 National Academy of Sciences, U.S.A. J:176587

Associated Alleles

Symbol	Name
Npc1^tm1Mbjg	NPC intracellular cholesterol transporter 1; targeted mutation 1, Joseph L Goldstein

Associated Genotypes

Allelic Composition	Genetic Background
Npc1^tm1Mbjg/Npc1^tm1Mbjg	involves: 129S6/SvEvTac * C57BL/6J