Phenotype Image Detail

Image

Caption

Neuron-derived Sema3e restricts vascular pathfinding in developing retinas. C) Whole-mount PECAM-1 IHC in P4 retinas. In the Sema3e^tm1Ddg/Sema3e^tm1Ddg (Sema3e^-/-) retina, the vascular network is disorganized in the upper-right quadrant. Note the attachment of hyaloid vessels to the retinal surface (arrowhead). Scale bars: 100 um (C).

Copyright

This image is from Fukushima Y, J Clin Invest 2011 May 2;121(5):1974-85 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:173943

Associated Alleles

Symbol	Name
Sema3e^tm1Ddg	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E; targeted mutation 1, David D Ginty

Associated Genotypes

Allelic Composition	Genetic Background
Sema3e^tm1Ddg/Sema3e^tm1Ddg	involves: 129P2/OlaHsd * C57BL/6