Phenotype Image Detail

Image

Caption

(N-P) Tert^tm1Leah/Tert^tm1Leah (TERT) knockout prevents telomere elongation in Pinx1^tm1.1Kplu/Pinx1⁺ MEFs at late passage, as determined by qFISH. (P) Tert^tm1Leah/Tert^tm1Leah knockout prevents anaphase brides and/or lagging chromosomes in Pinx1^tm1.1Kplu/Pinx1⁺ MEFs at late passage.

Copyright

This image is from Zhou XZ, J Clin Invest 2011 Apr 1;121(4):1266-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:171997

Associated Alleles

Symbol	Name
Pinx1^tm1.1Kplu	PIN2/TERF1 interacting, telomerase inhibitor 1; targeted mutation 1.1, Kun Ping Lu
Tert^tm1Leah	telomerase reverse transcriptase; targeted mutation 1, Lea Harrington

Associated Genotypes

Allelic Composition	Genetic Background
Pinx1^tm1.1Kplu/Pinx1^+ Tert^tm1Leah/Tert^tm1Leah	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N