Phenotype Image Detail

Image

Caption

Sixteen hours after mating of wild-type (Pla2g3^+/+) (panels a and b) and Pla2g3^tm1Murm/ Pla2g3^tm1Murm (Pla2g3^-/-) (panels c and d) male mice with female C57BL/6 mice, the uterine ducts were isolated from the females, and paraffin-embedded sections of the utero-tubal junction and lower part of the uterus (panel a, dashed lines) were stained with hematoxylin and eosin. Gross views of the cross-sections indicated the presence of seminal plasma in the uterine ducts in both wild-type (panels b and e) and mutant (panels g and j) mice. Boxed areas are magnified in panels c, d, f, h, i and k. Spermatozoa of wild-type mice were distributed in all areas of the uterine duct (panels c and f) and even in the oviduct (panel d; indicated by the arrow), whereas those of mutant mice remained in the lower uterus (panel k) and were barely found in the upper uterus (panel h) and oviduct (panel i).

Copyright

This image is from Sato H, J Clin Invest 2010 May 3;120(5):1400-14 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:161462

Associated Alleles

Symbol	Name
Pla2g3^tm1Murm	phospholipase A2, group III; targeted mutation 1, Makoto Murakami

Associated Genotypes

Allelic Composition	Genetic Background
Pla2g3^tm1Murm/Pla2g3^tm1Murm	involves: 129S/SvEv * C57BL/6J