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Caption (A and B) Blood glucose (A) and plasma insulin (B) concentrations in wild-type (WT) (n = 7), Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (Beta Cebpb-/-) (n = 9), Ins2Akita/Ins2Akita (Akita) (n = 7), and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (n = 14) mice in the fed state and at the indicated ages. Data are mean +/- SEM. *P < 0.05, ** P < 0.01, Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 versus Ins2Akita/Ins2Akita. (C) Pancreatic sections from 8-week-old wild-type (WT), Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (Beta Cebpb-/-), Ins2Akita/Ins2Akita (Akita), and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 (Akita;Beta Cebpb-/-) mice were stained with antibodies to insulin (red) and to glucagon (green). Scale bars: 100 um. (D) Quantitation of Beta cell mass in 8-week-old WT, Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0, Ins2Akita/Ins2Akita, and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice. Data are mean +/- SEM from 5 mice per genotype. *P <0.05. (E) Insulin content of the pancreas of WT, Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0, Ins2Akita/Ins2Akita, and Ins2Akita/Ins2Akita Cebpbtm1.1Maka/Cebpbtm1.1Maka Tg(Ins2-cre)23Herr/0 mice at 12 weeks of age. Data are mean +/- SEM from 4 mice per genotype. *P <0.05.
Copyright This image is from Matsuda T, J Clin Invest 2010 Jan;120(1):115-26 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156725
Associated
Alleles
Symbol Name
Cebpbtm1.1Maka CCAAT/enhancer binding protein (C/EBP), beta; targeted mutation 1.1, Masato Kasuga
Ins2Akita insulin II; Akita
Tg(Ins2-cre)23Herr transgene insertion 23, Pedro Luis Herrera
Associated
Genotypes
Allelic Composition Genetic Background
Cebpbtm1.1Maka/Cebpbtm1.1Maka
Ins2Akita/Ins2Akita
Tg(Ins2-cre)23Herr/0
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6NSlc * CBA/J
Ins2Akita/Ins2Akita involves: C57BL/6NSlc

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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory