Phenotype Image Detail

Image

Caption

Effects of Beta cell-specific ablation of Cebpb on glucose metabolism and islet morphology.(A) Pancreatic islets isolated from 24-week-old Cebpb^tm1.1Maka/Cebpb^tm1.1Maka control or Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0 (BetaCebpb-/-) mice were lysed and subjected to immunoblot analysis with antibodies to Cebpb and to Beta-actin (loading control). (B and C) Fed blood glucose (B) and plasma insulin (C) concentrations of control (open circles) or mutant (filled circles) mice at the indicated ages. Data are mean +/- SEM from at least 6 mice per genotype. (D) Immunostaining of pancreatic sections from 24-week-old control or mutant mice with antibodies to insulin (red) and to glucagon (green). Scale bars: 100 um.

Copyright

This image is from Matsuda T, J Clin Invest 2010 Jan;120(1):115-26 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:156725

Associated Alleles

Symbol	Name
Cebpb^tm1.1Maka	CCAAT/enhancer binding protein beta; targeted mutation 1.1, Masato Kasuga
Tg(Ins2-cre)23Herr	transgene insertion 23, Pedro Luis Herrera

Associated Genotypes

Allelic Composition	Genetic Background
Cebpb^tm1.1Maka/Cebpb^tm1.1Maka Tg(Ins2-cre)23Herr/0	involves: 129P2/OlaHsd * C57BL/6J * CBA/J