Phenotype Image Detail

Image

Caption

(A) Glycogen storage evidenced by PAS staining in skeletal muscle sections from wild-type (WT) and Pfkm^tm1Fbos/Pfkm^tm1Fbos (Pfkm^-/-) mice. Scale bar 50 um. (B) Transmission electron microscopic analysis of skeletal muscle. Arrows show glycogen storage and asterisks point to mitochondria. Scale bar 1 um. (C) Mutant mice showing severe muscle cramps after exercise (5 min). (D) ATP and ADP content was determined in perchloric extracts of skeletal muscle from wild-type and mutant mice, in rest and after exercise (5 min). Results are mean +/- SEM of five mice per group. *P<0.05 vs. wild-type.

Copyright

This image is from Garcia M, PLoS Genet 2009 Aug;5(8):e1000615, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:152153

Associated Alleles

Symbol	Name
Pfkm^tm1Fbos	phosphofructokinase, muscle; targeted mutation 1, Fatima Bosch

Associated Genotypes

Allelic Composition	Genetic Background
Pfkm^tm1Fbos/Pfkm^tm1Fbos	involves: 129S6/SvEvTac * C57BL/6J