Phenotype Image Detail

Image

Caption

Sagittal sutures in 1-week old wild-type, Lmna^Dhe/Lmna⁺ and Lmna^Dhe/Lmna^Dhe mice. Wild-type (+/+) mouse skull shows normal suture development (top), whereas Lmna^Dhe/Lmna⁺ (+/Dhe, middle) and Lmna^Dhe/Lmna^Dhe (Dhe/Dhe, bottom) mice have deficient cranial growth. The wild-type skulls shows normal histology, with the edges of the parietal bones (P) nearly overlapping (open arrowheads) and a dense growth of connective tissue surrounding the edges of the bones. In heterozygous mice, the bones do not reach one another, the bones themselves are thin, and the connective tissue between them is less dense. In homozygous mice, the phenotype is more severe, with a suture nearly a millimeter wide and the connective tissue in the gap loose and disorganized. 2 um Epon sections stained with toluidine blue.

Copyright

This image is from Odgren PR, PLoS One 2010;5(4):e9959, and is displayed under the terms of the Creative Commons Attribution 4.0 International License. J:160175

Associated Alleles

Symbol	Name
Lmna^Dhe	lamin A; disheveled hair and ears

Associated Genotypes

Allelic Composition	Genetic Background
Lmna^Dhe/Lmna^Dhe	B6(D2)-Lmna^Dhe/TyGrsrJ
Lmna^Dhe/Lmna^+	B6(D2)-Lmna^Dhe/TyGrsrJ