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Phenotype Image Detail
Caption Sagittal sutures in 1-week old wild-type, LmnaDhe/Lmna+ and LmnaDhe/LmnaDhe mice. Wild-type (+/+) mouse skull shows normal suture development (top), whereas LmnaDhe/Lmna+ (+/Dhe, middle) and LmnaDhe/LmnaDhe (Dhe/Dhe, bottom) mice have deficient cranial growth. The wild-type skulls shows normal histology, with the edges of the parietal bones (P) nearly overlapping (open arrowheads) and a dense growth of connective tissue surrounding the edges of the bones. In heterozygous mice, the bones do not reach one another, the bones themselves are thin, and the connective tissue between them is less dense. In homozygous mice, the phenotype is more severe, with a suture nearly a millimeter wide and the connective tissue in the gap loose and disorganized. 2 um Epon sections stained with toluidine blue.
Copyright This image is from Odgren PR, PLoS One 2010;5(4):e9959, an open-access article distributed under the terms of the Creative Commons Attribution License. J:160175
Symbol Name
LmnaDhe lamin A; disheveled hair and ears
Allelic Composition Genetic Background
LmnaDhe/LmnaDhe B6(D2)-LmnaDhe/TyGrsrJ
LmnaDhe/Lmna+ B6(D2)-LmnaDhe/TyGrsrJ

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MGI 6.13
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