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Phenotype Image Detail
Caption X-rays of 6 week-old wild-type (+/+; A, B, C) and LmnaDhe/Lmna+ (Dhe/+; D,E,F) hemisected skulls. Note lower bone mineral in cranial vault (compare A and D) in the mutant. Total skull length in D is 92% of A (white lines above, A & D). Diastema in E (mandibular arch: the upper white line in B and E) is 67% of that in B, and incisor length in E (the lower white line in B and E) is 87% of that in B. The entire margin of the parietal bone (indicated by white arrows in F) is radiolucent and visible, whereas it cannot be seen C. (G-L), Alizarin red stained skulls of 9 day-old LmnaDhe/LmnaDhe (Dhe/Dhe). (G,H), heterozygous mutant (I,J) and wild-type (K,L) mice. Overall deficient bone growth and mineralization are evident in homozygous and heterozygous skulls. Right-hand panels are slightly enlarged views of the skulls in the left panels. Note the deficient skull length and failure of mineralization to proceed, especially in the cranial vault, with large, open areas around the parietal and occipital bones (*). Bar in K=9.6 mm in A, D; 4.1 mm in B, E; 0.76 mm in C, F; 2 mm in G, I K; and 0.94 mm in H, J, L.
Copyright This image is from Odgren PR, PLoS One 2010;5(4):e9959, an open-access article distributed under the terms of the Creative Commons Attribution License. J:160175
Symbol Name
LmnaDhe lamin A; disheveled hair and ears
Allelic Composition Genetic Background
LmnaDhe/LmnaDhe B6(D2)-LmnaDhe/TyGrsrJ
LmnaDhe/Lmna+ B6(D2)-LmnaDhe/TyGrsrJ

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