Phenotype Image Detail

Image

Caption

A, wild-type otoconia can be easily detected under a light microscope when looking at isolated inner ears. Two bright reflected areas represent the otoconia of the saccule and utricle of newborn mice. Slc26a4^loop/Slc26a4^loop mutant mice lack the bright reflection, and instead, a dark hole appears when looking through the oval window (arrowheads). B, SEM of 2-month-old utricle shows thousands of otoconia (inset) that cover the sensory epithelium in a wild-type mouse, whereas a giant stone is appearing at the mutant utricle. C, imaging of the gelatinous matrix (otoconial membrane) reveals its normal structure in wild-type mice, which is characterized by typical pores. In the mutants, the otoconial membrane is dissociated and severed. D, high resolution images of the underlying hair cells show that mutant vestibular hair cells appear to be normal. Scale bars equal 500 um in panel A, 100 um in B, 5 um in C and D. n = 4.

Copyright

This image is from Dror AA, J Biol Chem 2010 Jul 9;285(28):21724-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:163655

Associated Alleles

Symbol	Name
Slc26a4^loop	solute carrier family 26, member 4; loop

Associated Genotypes

Allelic Composition	Genetic Background
Slc26a4^loop/Slc26a4^loop	involves: C3HeB/FeJ