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Phenotype Image Detail
Image
Caption (A) Wild-type (+/+), Ptrh2tm1.1Eruo/Ptrh2+ (+/-), and Ptrh2tm1.1Eruo/Ptrh2tm1.1Eruo (KO) embryos delivered by C-section are shown. (B) Representative mutant and wild-type littermate mice are depicted in dorsal and side shots at approximately P10. (C and D) Mutant mice exhibit delayed development. H&E stained sections of the kidney (C) and the muscle (D). The glomeruli are smaller in the kidney than in wild-type control. A representative glomerulus is encircled. The fibers are smaller in epaxial muscle in the mutant mice. This size difference was particularly striking for the older mice (P<0.001; one-way ANOVA and Tukey test). (Size bars: 50 um).
Copyright This image is from Kairouz-Wahbe R, Proc Natl Acad Sci U S A 2008 Feb 5;105(5):1528-32. Copyright 2008 National Academy of Sciences, U.S.A. J:131853
Associated
Alleles
Symbol Name
Ptrh2tm1.1Eruo peptidyl-tRNA hydrolase 2; targeted mutation 1.1, Erkki Ruoslahti

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory