Phenotype Image Detail

Image

Caption

Cross-sections of E9.5 placentas from wild-type (WT, A) and Epn1^tm1Ocr/Epn1^tm1Ocr Epn2^tm1Ocr/Epn2^tm1Ocr (DKO, B) embryos and cross-section of the yolk sac from a mutant embryo (C). The wild-type placenta is much thicker than the mutant placenta, and only some layers are included in the picture (the decidual and giant cell layers are not displayed). In the wild-type, but not in the mutant placenta, there is intermingling of embryonal (E) and maternal (M) vessels. As a result, the labyrinthine layer is missing in the mutant placenta. The cross-section of a mutant yolk sac reveals the presence of nucleated blood cells in the vascualr sinusoids (arrowheads), thus showing occurrence of hematopoiesis. De, decidua; GC, giant cell layer; SP, spongiotrophoblast layer; La, labyrinthine layer; CP, chorionic plate; AL, allantois.

Copyright

This image is from Chen H, Proc Natl Acad Sci U S A 2009 Aug 18;106(33):13838-43. Copyright 2009 National Academy of Sciences, U.S.A. J:151951

Associated Alleles

Symbol	Name
Epn1^tm1Ocr	epsin 1; targeted mutation 1, Ottavio Cremona
Epn2^tm1Ocr	epsin 2; targeted mutation 1, Ottavio Cremona

Associated Genotypes

Allelic Composition	Genetic Background
Epn1^tm1Ocr/Epn1^tm1Ocr Epn2^tm1Ocr/Epn2^tm1Ocr	B6.129X1-Epn1^tm1Ocr Epn2^tm1Ocr