Phenotype Image Detail

Image

Caption

Analysis of hemotoxylin and eosin stained cross-sections from wild-type and Slc4a11^{Gt(OST443317)Lex}/Slc4a11^{Gt(OST443317)Lex} mouse corneas. A, cross-sections of the central cornea were examined for total thickness (t), epithelial thickness (e), and the height of the basal epithelial cell layer (b). Wild-type (Slc411^+/+) (B) and Slc4a11^{Gt(OST443317)Lex}/Slc4a11^{Gt(OST443317)Lex} (Slc4a11^-/-) (C) corneal cross-sections have similar total corneal and epithelial thickness. Basal cell height was greater in mutant mice. Comparison of corneal architecture in wild-type and mutant mice. Total corneal thickness (D) and epithelial thickness (E) did not differ significantly between the two groups; however, basal cell height (F) and ratio of basal cell height to epithelial thickness (G) were significantly greater (asterisks) in mutant mice than in wild-type mice. The stromal layer appeared normal in thickness but more disorganized.

Copyright

This image is from Lopez IA, J Biol Chem 2009 Sep 25;284(39):26882-96 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:155513

Associated Alleles

Symbol	Name
Slc4a11^Gt(OST443317)Lex	solute carrier family 4, sodium bicarbonate transporter-like, member 11; gene trap OST443317, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Slc4a11^Gt(OST443317)Lex/Slc4a11^Gt(OST443317)Lex	involves: 129S5/SvEvBrd * C57BL/6J