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Phenotype Image Detail
Image
Caption Abca12tm1Lex/Abca12tm1Lex P0 pups are able to inflate their lungs if maintained in a hydrating environment. A, Abca12tm1Lex/Abca12tm1Lex (Abca12-/-) P0 lungs float in 1 x PBS indicating an ablility to inflate the lung. B, Histological sections of mutant lung shows inflated alveoli relative to the corresponding littermate wild-type (Abca12+/+) lungs. C, electron micrographs of the mutant lungs demonstrate type II alveolar cells form lamellar bodies and secrete surfactant.
Copyright This image is from Zuo Y, J Biol Chem 2008 Dec 26;283(52):36624-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:144062
Associated
Alleles
Symbol Name
Abca12tm1Lex ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1, Lexicon Genetics
Associated
Genotypes
Allelic Composition Genetic Background
Abca12tm1Lex/Abca12tm1Lex involves: 129S/SvEvBrd * C57BL/6J

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory