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Phenotype Image Detail
Caption Loss of ABCA12 transport function induces hyperkeratosis of the stratum corneum and disrupts interstitial lamellar lipid structure. A, electron micrograph of the wild-type (Abca12 +/+) epidermis showing normal stratum corneum (SC) (10,000x). E, Abca12tm1Lex/Abca12tm1Lex (Abca12-/-) epidermis showing massive hyperkeratosis of the SC (2000x magnification, which was required to capture the expanded SC). B, interstitial spaces of the wild-type SC demonstrate the lipid lamellar structures required for permeability barrier function (arrow, 80,000x), which are absent and replaced by a disorganized multivesicular material in the interstitial spaces of the mutant SC (F, arrow, 80,000x). C and D, lamellar storage bodies present in the wild-type stratum granulosum (C and D, 150,000x). The mutant stratum granulosum lacked lamellar storage bodies but did contain numerous multivesicular bodies, the presumptive precursor of the lamellar body (G and H, 150,000x).
Copyright This image is from Zuo Y, J Biol Chem 2008 Dec 26;283(52):36624-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:144062
Symbol Name
Abca12tm1Lex ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1, Lexicon Genetics
Allelic Composition Genetic Background
Abca12tm1Lex/Abca12tm1Lex involves: 129S/SvEvBrd * C57BL/6J

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