Phenotype Image Detail

Image

Caption

Development of the epidermal permeability barrier. A, littermate E18.5 embryos stained with toluidine blue indicates loss of ABCA12 function (Abca12^tm1Lex/Abca12^tm1Lex) increases inward permeability to this dye. B, loss of ABCA12 function significantly increases outward transepidermal water loss rates as measured in littermate E18.5 embryos using the gravimetric assay. (Abca12^+/+, n=3; Abca12^+/-, n=7; Abca12^-/-, n=6; +/- S.E.: p= 0.11, Abca12 ^+/+ versus Abca12 ^+/-; p=0.00005, Abca12^+/+ versus Abca12^-/-).

Copyright

This image is from Zuo Y, J Biol Chem 2008 Dec 26;283(52):36624-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from \JBiolChem(18957418|JBC|). J:144062

Associated Alleles

Symbol	Name
Abca12^tm1Lex	ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1, Lexicon Genetics

Associated Genotypes

Allelic Composition	Genetic Background
Abca12^tm1Lex/Abca12^tm1Lex	involves: 129S/SvEvBrd * C57BL/6J