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Phenotype Image Detail
Image
Caption Development of the epidermal permeability barrier. A, littermate E18.5 embryos stained with toluidine blue indicates loss of ABCA12 function (Abca12tm1Lex/Abca12tm1Lex) increases inward permeability to this dye. B, loss of ABCA12 function significantly increases outward transepidermal water loss rates as measured in littermate E18.5 embryos using the gravimetric assay. (Abca12+/+, n=3; Abca12+/-, n=7; Abca12-/-, n=6; +/- S.E.: p= 0.11, Abca12 +/+ versus Abca12 +/-; p=0.00005, Abca12+/+ versus Abca12-/-).
Copyright This image is from Zuo Y, J Biol Chem 2008 Dec 26;283(52):36624-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:144062
Associated
Alleles
Symbol Name
Abca12tm1Lex ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1, Lexicon Genetics
Associated
Genotypes
Allelic Composition Genetic Background
Abca12tm1Lex/Abca12tm1Lex involves: 129S/SvEvBrd * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory