About   Help   FAQ
Phenotype Image Detail
Image
Caption Loss of ABCA12 causes neonatal lethality and epidermal hyperkeratosis. A, Abca12tm1Lex/Abca12tm1Lex (Abca12 -/-) day 18.5 embryos (E18.5) when kept hydrated are similar in size and weight to wild-type (Abca +/+) littermates, but after exposure to air rapidly dry out and become encased in a collodion-like shell (B). The mutant epidermis displays a markedly thickened, hyperkeratotic epidermis as shown in hematoxylin and eosin stained skin sections; scale bar, 20 um (C) (sc, stratum corneum; sg, stratum granulosum; ss, stratum spinosum; sb, stratum basale).
Copyright This image is from Zuo Y, J Biol Chem 2008 Dec 26;283(52):36624-35 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:144062
Associated
Alleles
Symbol Name
Abca12tm1Lex ATP-binding cassette, sub-family A (ABC1), member 12; targeted mutation 1, Lexicon Genetics
Associated
Genotypes
Allelic Composition Genetic Background
Abca12tm1Lex/Abca12tm1Lex involves: 129S/SvEvBrd * C57BL/6J

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory