Phenotype Image Detail

Image

Caption

Histology of the retina. A: Retina from a wild-type female, with normal architecture, including inner nuclear layer (INL), outer nuclear layer (ONL), ganglion cell layer (GCL), and photoreceptors (PhR). B: Retina from a Clcn2^tm1Mlv/Clcn2^tm1Mlv female, with decreased outer nuclear layer, and a single row of photoreceptor nuclei remaining adjacent to the inner nuclear layer. C: Retina from a mutant male, which has lost all of the photoreceptor nuclei, leaving only the inner nuclear layer.

Copyright

This image is from Nehrke K, J Biol Chem 2002 Jun 28;277(26):23604-11 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:77673

Associated Alleles

Symbol	Name
Clcn2^tm1Mlv	chloride channel, voltage-sensitive 2; targeted mutation 1, James E Melvin

Associated Genotypes

Allelic Composition	Genetic Background
Clcn2^tm1Mlv/Clcn2^tm1Mlv	involves: C57BL/6