Phenotype Image Detail

Image

Caption

Adrenal histology, lipid content and Scarb1 (SR-BI) mRNA levels in wild-type and Lcat^tm1Hgc/Lcat^tm1Hgc mice. A: Gross appearance of adrenal glands from male wild-type (+/+) and Lcat^tm1Hgc/Lcat^tm1Hgc (-/-) mice. The scale shown is in millimeters. B: Oil Red O stained frozen sections of the adrenals showing complete depletion of neutral lipid store in the adrenal cortex of male mutants. C: Quantification of tissue cholesterol in the adrenals of wild-type and mutant mice. Bar graph represents the means +/- S.D. from three mice in each group. *,p=0.008, and **, p=0.09, compared with their respective wild-type controls. D: Quantification of mouse SR-BI mRNA expression by Northern blot in wild-type and mutant mice. Phosphorlmager quantification of the SR-BI mRNA bands after normalization to the Beta-actin level. The bar graph represents the means +/- S.D. from five mice in each group. *, p<0.05 compared with wild-type control.

Copyright

This image is from Ng DS, J Biol Chem 1997 Jun 20;272(25):15777-81 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:41208

Associated Alleles

Symbol	Name
Lcat^tm1Hgc	lecithin cholesterol acyltransferase; targeted mutation 1, Edward M Rubin

Associated Genotypes

Allelic Composition	Genetic Background
Lcat^tm1Hgc/Lcat^tm1Hgc	involves: C57BL/6 * DBA