Phenotype Image Detail

Image

Caption

From the emergence of secondary lens fibers onwards, Nrcam^tm1Fgr/Nrcam^tm1Fgr (NrCAM -/-) lens fibers develop rounded instead of elongated shape, indicating loss of cell-cell contact. The phenotype is progressive and leads to a disintegration of lens fibers and accumulation of cellular debris. (A) Mutant E14.5n longitudinal section, HE stained. (B and C) Mutant E18 longitudinal sections, HE stained. (D) Mutant P12 noncentral longitudinal section, anterior region, TB stained. (C-K) Postions of sections in the lens are indicated in l. (E) 2 month-old wild-type (+/+) region in noncentral longitudinal section, HE stained. (F) Same as e, but with mutants. (G-H) 2 month-old mutant central longitudinal section, TB stained. (G) One-third of the way to the center side-front region. (H) Half-way to the center posterior region. (I-K) 8 month old mutant lens in longitudinal noncentral section, HE stained. (I) Marginal region. (J) Anterior region. (K) Posterior region. *Cellular debris; arrowheads, intensely stained rounded cell; arrows, examples of secondary fiber cells in the process of rounding up due to contact loss of neighboring cells; open arrows, cells in process of disintergration.

Copyright

This image is from More MI, J Cell Biol 2001 Jul 9;154(1):187-96, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:70385

Associated Alleles

Symbol	Name
Nrcam^tm1Fgr	neuronal cell adhesion molecule; targeted mutation 1, Fritz G Rathjen