Phenotype Image Detail

Image

Caption

Macroscopic overview of both wild-type and Kif3a^tm1Noh/Kif3a^tm1Noh embryos at 9.5 dpc. (A) Lateral view of a wild-type embryo. Normal development of somites and the nervous system can be observed. (B) Same view of a homozygous embryo. Note the severe degeneration of the lower half of the body accompanied by thin neural tube wall. (C) Dorsal view of a homozygous embryo, exhibiting a staggered midline structure with disorganized somites. (D) Extensive pericardial effusion (arrow) resulting in circulatory insufficiency. Bar, 1 mm.

Copyright

This image is from Takeda S, J Cell Biol 1999 May 17;145(4):825-36, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:55332

Associated Alleles

Symbol	Name
Kif3a^tm1Noh	kinesin family member 3A; targeted mutation 1, Nobutaka Hirokawa

Associated Genotypes

Allelic Composition	Genetic Background
Kif3a^tm1Noh/Kif3a^tm1Noh	involves: 129S4/SvJae * C57BL/6J