Phenotype Image Detail

Image

Caption

Axonal morphology in dorsal and ventral roots of old wild-type, Nefm^tm1Ral/Nefm^tm1Ral, Nefh^tm1Ral/Nefh^tm1Ral, and Nefh^tm1Ral/Nefh^tm1Ral Nefm^tm1Ral/Nefm^tm1Ral mice. Light microscopy of toluidine blue-stained cross sections of L4 dorsal (A,C,E and G) or L4 ventral (B,D,F and H) roots from 2 year old wild-type (WT, A and B) Nefm^tm1Ral/Nefm^tm1Ral (NF-M, C and D), Nefh^tm1Ral/Nefh^tm1Ral (NF-H, E and F), or Nefm^tm1Ral/Nefm^tm1Ral Nefh^tm1Ral/Nefh^tm1Ral (NF-M/H, G and H) mice. Insets show cross sections of whole roots at lower magnification. The ventral root axons in the Nefm^tm1Ral/Nefm^tm1Ral and double homozygous mutants appear shrunken and frequently irregular in shape. In the dorsal roots only axons in the double homozygous mutants are affected by the atrophic process. Bar, 10 um.

Copyright

This image is from Elder GA, J Cell Biol 1999 Jul 12;146(1):181-92, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:77656

Associated Alleles

Symbol	Name
Nefh^tm1Ral	neurofilament, heavy polypeptide; targeted mutation 1, Robert A Lazzarini
Nefm^tm1Ral	neurofilament, medium polypeptide; targeted mutation 1, Robert A Lazzarini

Associated Genotypes

Allelic Composition	Genetic Background
Nefm^tm1Ral/Nefm^tm1Ral	involves: 129S1/Sv * 129X1/SvJ
Nefh^tm1Ral/Nefh^tm1Ral	involves: 129S1/Sv * 129X1/SvJ
Nefh^tm1Ral/Nefh^tm1Ral Nefm^tm1Ral/Nefm^tm1Ral	involves: 129S1/Sv * 129X1/SvJ