Phenotype Image Detail

Image

Caption

Ultrastructural analysis of paw epidermis from wild-type (a), Krt10^tm1Tmm/Krt10⁺ (b) and Krt10^tm1Tmm/Krt10^tm1Tmm (c and d) mice. (a) Normal ridged epidermis. Cytokeratin filament bundles are arranged in bundles of varying length. Note the prominent keratohyalin granules (arrowheads). bc, basal cell. (b) Spinous cell containing areas of filament free cytoplasm as well as abnormal cytokeratin aggregates (arrow). m, mitochondrion. (c) Granular cell. Note the overall sparsity of cytokeratin filaments. Remaining filaments are associated with desmosomes (arrowhead) and keratohyalin (kh). (d) Overview. Basal cells are normal. Suprabasal cells show electron dense irregularly shaped aggregates located near the cell membrane (arrows). Note the highly electron-lucent cytoplasm (asterisk) of granular cells. Bars: (a and d) 2 um; (b and c) 0.5 um.

Copyright

This image is from Porter RM, J Cell Biol 1996 Mar;132(5):925-36, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:31853

Associated Alleles

Symbol	Name
Krt10^tm1Tmm	keratin 10; targeted mutation 1, Thomas M Magin

Associated Genotypes

Allelic Composition	Genetic Background
Krt10^tm1Tmm/Krt10^tm1Tmm	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)
Krt10^tm1Tmm/Krt10^+	either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * BALB/c * C57BL/6)