Phenotype Image Detail

Image

Caption

Ultrastructure of other stratified squamous epithelia of neonatal Krt14^tm1Efu/Krt14^tm1Efu mice. Tissues from 2 day old Krt14^tm1Efu/Krt14^tm1Efu and Krt14^tm1Efu/Krt14⁺ mice were fixed and processed for electron microscopy. Sections shown are from: (a) cornea of homozygous mutant mouse. Asterisks denote cytolysis. (b) cornea of heterozygous mouse. Inset, thin and sparse keratin filament bundles (Kf) typical of normal corneal basal cells. (c) Basal cells of dorsal portion of a homozygous mutant tongue. Note presence of small keratin filament bundles, which were more prevalent than those of homozygous mutant epidermis. Note also the denser filaments surrounding desmosomes (De) and hemidesmosomes (arrows). (d) Basal cells in dorsal portion of a heterozygous tongue. Note thick keratin filament bundles (Kf) typical of wild-type basal cells of both tongue and epidermis. Frames e and f. Basal cells from a homozygous mutant forestomach (e) and esophagus (f). Note long and relatively thin keratin filament bundles (Kf), typical of wild-type basal cells from these tissues. In fact, very little difference was detected between the wild-type and mutant basal cells from these two tissues. Arrow in f denotes direction of basement membrane. Nu, nuclei; BL, basal lamina; Mi, mitochondria. Bars: (a) 0.8 um; (b) 1.3 um; (b, inset) 0.35 um; (c) 0.55 um; (d) 0.45 um; (e and f) 0.4 um.

Copyright

This image is from Lloyd C, J Cell Biol 1995 Jun;129(5):1329-44, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:25763

Associated Alleles

Symbol	Name
Krt14^tm1Efu	keratin 14; targeted mutation 1, Elaine Fuchs

Associated Genotypes

Allelic Composition	Genetic Background
Krt14^tm1Efu/Krt14^tm1Efu	involves: 129