Phenotype Image Detail

Image

Caption

Light micrographs of the testes (a-c) and epididymis (d-f) of wild-type (HSL^+/+) (a,d) and (HSL^-/-) (b,c,e,f) mice at 14 months (a-e) and 10 months (f) of age. In (a), the seminiferous epithelium (SE) shows a full complement of germ cells including elongating speramtids (squares). In (b), seminiferous tubules are of smaller size and while some reveal late spermatids (squares) others do not. Some tubules have an irregular profile and show a dramatic decrease of germ cells (solid asterisks). In (c), while come tubules reveal a more-or-less normal epithelium (hollow asterisks), others are grossly depleted of germ cells (solid asterisks). In (d), the epididymal lumen of the cauda region is filled with the heads of sperm (circles) some of which may represent degenerating germ cells, as well as normal and abnormal sperm heads. Lu, lumen; E, epithelium. Original magnification (a,b,d-f: 200x; c, 75x).

Copyright

This image is from Hermo L, Mol Reprod Dev 2008 Apr;75(4):565-77, and is displayed with the permission of Wiley-Blackwell, who owns the Copyright. J:134794

Associated Alleles

Symbol	Name
Lipe^tm1Gam	lipase, hormone sensitive; targeted mutation 1, Grant A Mitchell