Phenotype Image Detail

Image

Caption

A: Gross appearance of adrenal glands taken from wild-type (+/+), Nr3c1^tm1Dage/Nr3c1⁺ (+/L) and Nr3c1^tm1Dage/Nr3c1^tm1Dage (L/L) littermates. B: Mean adrenal weight of 3-4 month old female and male mutant mice and wild-type littermates. Adrenal weight is expressed as milligrams/g body weight. Heterozygous and homozygous mouse adrenals are significantly smaller than those from wild-type littermates in both male and female mice (*, p<0.001 versus +/+). C: Low (x10) and high (x40) power views of hematoxylin an eosin-stained adrenal tissue sections derived from a wild-type mouse (left panel) and mutant mouse (right panel). There is marked thinning of the adrenal cortex (bracketed) in mutant mice. D: Mean adrenal cortical thickness in wild-type (n=13), heterozygous (n=14) and homozygous (n=13) mice. There was a marked and highly dignificant reduction in adrenal cortical thickness in mutant mice.

Copyright

This image is from Zhang J, J Biol Chem 2009 Mar 6;284(10):6249-59 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:147914

Associated Alleles

Symbol	Name
Nr3c1^tm1Dage	nuclear receptor subfamily 3, group C, member 1; targeted mutation 1, David Geller

Associated Genotypes

Allelic Composition	Genetic Background
Nr3c1^tm1Dage/Nr3c1^tm1Dage	involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL
Nr3c1^tm1Dage/Nr3c1^+	involves: 129P1/ReJ * C57BL/6 * C57BL/6J * SJL