Phenotype Image Detail

Image

Caption

Phenotypes of wild-type and Pkp2^tm1Wbm/Pkp2^tm1Wbm (PKP2-/-) embryos at E10.75. A and B: External appearance of embryos. In the Pkp2^tm1Wbm/Pkp2^tm1Wbm embryo, blood has accumulated in the pericardial and peritoneal cavities, which are connected at the embryonal stage. C-F: The vasculature of the yolk sac contains red blood cells in the wild-type (WT), but not in the mutant embryos, as shown by whole-mount photography (C and D) and microscopy of hematoxylin and eosin-stained sections of endothelia (E and F). Bars: 1000um, A,B,C,D; 100um, E and F.

Copyright

This image is from Grossmann KS, J Cell Biol 2004 Nov 11;167(1):149-60, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:93314

Associated Alleles

Symbol	Name
Pkp2^tm1Wbm	plakophilin 2; targeted mutation 1, Walter Birchmeier

Associated Genotypes

Allelic Composition	Genetic Background
Pkp2^tm1Wbm/Pkp2^tm1Wbm	involves: C57BL/6