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Phenotype Image Detail
Image
Caption A: Gross examinaton of whole mount wild-type (+/+) and Rb1cc1tm1.2Guan/Rb1cc1tm1.2Guan(delta/delta) embryos at E12.5, E14.5 and E15.5. Note the paleness of mutant embryos compared with wild-type littermates at E14.5 and E15.5. B: Histological sections from the heart of wild-type and mutant embryos at E14.5. The heart in the mutant embryo shows marked left ventricular dilation and a sparsely cellular thin wall that is composed of wisps of thin trabecular myocardium and is devoid of the compact subepicardial myocardium. fw, left ventricular free wall; tm, trabecular myocardium. C: Histological sections of skin from the dorsum of wild-type and mutant embryos at E14.5. The marked expansion of the subcutis, the mild expansion of the dermis, and the thin, undulating epidermis are indicative of acute edema. ed, epidermis; d, dermis; sc, subcutis; bf, frown fat. D: Histological secions of liver of wild-type and mutant embryos at E14.5. Liver from mutant embryo showed disrupted architecture with loss of hepatocytes and multifocal variable sized hemorrhages. Also note that many hepatocytes have condensed nuclei (karyopyknosis; red arrow) or fragmented nuclei (karyorrhexis; yellow arrow) or lost their nuclei (karyolysis; black arrow) in the mutant embryo (bottom right).
Copyright This image is from Gan B, J Cell Biol 2006 Oct 9;175(1):121-33, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:114498
Associated
Alleles
Symbol Name
Rb1cc1tm1.2Guan RB1-inducible coiled-coil 1; targeted mutation 1.2, Jun-Lin Guan
Associated
Genotypes
Allelic Composition Genetic Background
Rb1cc1tm1.2Guan/Rb1cc1tm1.2Guan involves: 129P2/OlaHsd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory