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Phenotype Image Detail
Image
Caption Transmission electron micrographs of the terminal air sacs of E18.5 wild-type and Fras1tm1Chpk/Fras1tm1Chpk lungs. A and B: Ultrastructural analysis of the interface between endothelial and type I pneumocytes. The basement membrane (demarcated by arrowheads) appears significantly wider and less dense in mutants (B) compared with wild-type (A). C: Detachment of an endothelial cell from a type I pneumocyte (arrowheads) in mutant lungs. D: Extravasated erythrocytes (arrowheads) are frequently encountered in variable numbers in the respiratory lumen of mutant lungs. Abbreviations: lu, respiratory lumen; n, endothelial cell nucleus; p, type I pneumocyte; ery, erythrocyte. Scale bar: A-C, 200 nm; D, 1 um.
Copyright This image is from Petrou P, J Biol Chem 2005 Mar 18;280(11):10350-6 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:137010
Associated
Alleles
Symbol Name
Fras1tm1Chpk Fraser extracellular matrix complex subunit 1; targeted mutation 1, George Chalepakis
Associated
Genotypes
Allelic Composition Genetic Background
Fras1tm1Chpk/Fras1tm1Chpk involves: 129S1/Sv * 129X1/SvJ * NMRI

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory