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Image
Caption A: In adult Hsd11b2tm1Yko/Hsd11b2tm1Yko mice, the distal tubules (d) show considerable enlargement: the tubular diameter is increased threefold compared with the distal tubule in the wild-type mice (B). Note that the proximal tubules (p) and glomeruli (g) are unaffected in the mutant mice. C: Hyperplasia is apparent in the mutant mouse distal tubule (d), which shows over 20 cells in the cross-sectional profile compared with (D) the four to six cells observed in the wild-type. E: The distal tubular enlargement (d) is evident in mutant mice at the anatomical origin of the distal tubule at the juxtaglomerular apparatus (j) adjacent to the glomerulus (g), compared with (F) the nonenlarged wild-type distal tubule. md, macula densa. G: Proximal tubule (p) is normal in mutant kidneys. Mutant proximal tubules are indistinguishable from (H) wild-type proximal tubules. The tubules are of similar diameter and cell number in cross section. They are lined by cubiodal cells with granular cytoplasm and a brush border in both mice. The same magnification was used in mutant and corresponding wild-type control photographs. In A and B, H&E x60; in C and D, H&E x120; in E-H, H&E x180.
Copyright This image is from Kotelevtsev Y, J Clin Invest 1999 Mar;103(5):683-9 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:53391
Associated
Alleles
Symbol Name
Hsd11b2tm1Yko hydroxysteroid 11-beta dehydrogenase 2; targeted mutation 1, Yuri V Kotelevtsev
Associated
Genotypes
Allelic Composition Genetic Background
Hsd11b2tm1Yko/Hsd11b2tm1Yko involves: 129P2/OlaHsd * MF1

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory