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Phenotype Image Detail
Image
Caption Lungs of newborn Slc27a4tm1Wsr/Slc27a4tm1Wsr (Fatp4 -/-) mice and wild-type (Fatp4+/+) control littermates. A: Severe atelectasis of the lung in mutant mice. Mutant lungs, stained with hematoxylin and eosin, exhibit a reduced extension of the alveolae and an increase in width of the cellular alveolar septae. Bars, 100 um. B: Ultrastructural analysis of type II alveolar cells and alveolar surfactant in mutant mice (ruthenium tetroxide fixation). Lung tissue was obtained immediately after birth and prepared for EM. Extracellular forms of surfactant, which can be detected in both wild-type and mutant mice without distinction between genotypes, are marked by arrows. Bars, 5 um.
Copyright This image is from Herrmann T, J Cell Biol 2003 Jun 23;161(6):1105-15, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:84096
Associated
Alleles
Symbol Name
Slc27a4tm1Wsr solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Wolfgang Stremmel
Associated
Genotypes
Allelic Composition Genetic Background
Slc27a4tm1Wsr/Slc27a4tm1Wsr involves: 129P2/OlaHsd * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory