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Phenotype Image Detail
Caption Disturbed epidermal barrier in Slc27a4tm1Wsr/Slc27a4tm1Wsr mice. A: Diffusion of Lucifer yellow in neonatal mice. The fluorescent dye Lucifer yellow did not pass the upper layers of the stratum corneum in wild-type (Fatp4 +/+) neonatal mice. In contrast, in Slc27a4tm1Wsr/Slc27a4tm1Wsr (Fatp4 -/-) pups, it permeated the entire epidermis. Bars, 50 um. B: Access of X-gal to skin of embryonic day 18.5 mice. Slc27a4tm1Wsr/Slc27a4+ (Fatp4 +/-) epidermis is impermeable of X-gal. In contrast, X-gal permeates mutant skin, where it is cleaved by endogenous beta-galactosidase activity to produce a colored precipitate. A heterozygous mouse is shown as a control to exclude false-positive staining due to beta-galactosidase encoded by the lacZ gene of the mutant Slc27a4 allele.
Copyright This image is from Herrmann T, J Cell Biol 2003 Jun 23;161(6):1105-15, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:84096
Symbol Name
Slc27a4tm1Wsr solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Wolfgang Stremmel
Allelic Composition Genetic Background
Slc27a4tm1Wsr/Slc27a4tm1Wsr involves: 129P2/OlaHsd * C57BL/6

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