Phenotype Image Detail

Image

Caption

Gross analysis of newborn wild-type and Slc27a4^tm1Wsr/Slc27a4^tm1Wsr littermates. A-C: Gross morphology of wild-type (Fatp4 +/+) and Slc27a4^tm1Wsr/Slc27a4^tm1Wsr (Fatp4 -/-) neonates. At birth, mutant progeny were smaller and had a markedly abnormal appearance with facial dysmorphis, a compressed torso, and a taut skin exhibiting a scaly, wrinkle-free surface and extending over and covering the proximal extremities, the joints of which were fixed in flexion contracture. D: Alcian blue/Alizarin red S staining of wild-type and mutant skeletons revealed no gross morphological differences, neither in bone nor in cartilage. The flexion joint contractures persisted after the staining procedure.

Copyright

This image is from Herrmann T, J Cell Biol 2003 Jun 23;161(6):1105-15, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:84096

Associated Alleles

Symbol	Name
Slc27a4^tm1Wsr	solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Wolfgang Stremmel

Associated Genotypes

Allelic Composition	Genetic Background
Slc27a4^tm1Wsr/Slc27a4^tm1Wsr	involves: 129P2/OlaHsd * C57BL/6