Phenotype Image Detail

Image

Caption

Phenotypes of Lmna^tm1Lgf/Lmna⁺ mice. B: Retarded growth in male and female Lmna^tm1Lgf/Lmna⁺ (Lmna^HG/+) mice. Body weight curves are shown for male heterozygous mice (n = 8) and littermate male wild-type (Lmna^+/+) mice (n = 6) and for female heterozygous mice (n = 8) and littermate female wild-type mice (n = 7). Error bars for female mice and male heterozygous mice are too small to be seen. (C) Reduced survival of heterozygous (n = 42) and Lmna^tm1Lgf/Lmna^tm1Lgf (Lmna^HG/HG) (n = 12) mice. (D) Representative H&E-stained sections of skin from a 6-month-old heterozygous mouse and a littermate wild-type mouse; n = 4 mice of each genotype examined. (E) Body fat in heterozygous (n = 4) versus wild-type mice (n = 3) at 2 months of age (P = 0.2); heterozygous (n = 8) versus wild-type mice (n = 8) at 4 months of age (P < 0.0001); and heterozygous (n = 5) versus wild-type mice (n = 6) at 7 months of age (P < 0.0001). Original magnification, x20.

Copyright

This image is from Yang SH, J Clin Invest 2006 Aug;116(8):2115-21 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:113119

Associated Alleles

Symbol	Name
Lmna^tm1Lgf	lamin A; targeted mutation 1, Loren G Fong

Associated Genotypes

Allelic Composition	Genetic Background
Lmna^tm1Lgf/Lmna^+	involves: 129P2/OlaHsd * C57BL/6