Phenotype Image Detail

Image

Caption

Cross-section of the kidney of control (A) and Ren1^tm1Afu/Ren1^tm1Afu (B) mice. Hydronephrosis with atrophic papillae is prominent in the kidneys of mutant mice. Scale bars, 1 mm. Morphology of the cells of the macula densa. Macula densa in mutant mice was characterized by the increase of macula densa number (D) or by the marked accumulation of nuclei like as pseudostratified epithelium (E), although the control mice show simple plaque of distal tubule cells (C). Scale bars, 25 um. Electron microscopy revealed that juxtaglomerular cells of the mutant mice were completely devoid of the storage/secretory granules (G) typically present in wild-type controls (F). Scale bars; 0.25 um.

Copyright

This image is from Yanai K, J Biol Chem 2000 Jan 7;275(1):5-8 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:59299

Associated Alleles

Symbol	Name
Ren1^tm1Afu	renin 1 structural; targeted mutation 1, Akiyoshi Fukamizu

Associated Genotypes

Allelic Composition	Genetic Background
Ren1^tm1Afu/Ren1^tm1Afu	involves: C57BL/6 * CBA