Phenotype Image Detail

Image

Caption

Parasagittal sections of the heart of term wild-type (a), Ece1^tm1Reh/Ece1^tm1Reh (ECE-1^-/-) (b), and Ece1^tm1Reh/Ece1^tm1Reh Ece2^tm1Ywa/Ece2^tm1Ywa (ECE-1^-/-; ECE-2^-/-) embryos (c and d) and frontal sections of double mutant embryos (e and f) stained with hematoxylin and eosin. Original magnification is x11. (a) The interventricular septum (ivs) and aortic outflow (Ao) are seen. (b) Overriding of aorta with a small VSD (arrowhead) is seen in the single mutant embryo. (c) Persistent truncus arteriosus in a double mutant embryo. One outflow (arrow) is separated into aortic outflow (Ao) and pulmonary (P) outflows. A large VSD (arrohead) is shown. Displacement of the left AV valve (asterisk) is seen, opening toward the VSD. (d) Aorticopulmonary window in a double mutant embryo. Septation of the aortic and pulmonary outflow tracts is incomplete at the base of the outflow tract (arrow). Note that the pulmonary outflow becomes the dorsal arota (da) via the ductus arteriosus (dc). Pa, pulmonary artery. (e) Pulmonary and aortic outflow tracts originate from the right ventricle (DORV) in a double mutant embryo. A large conotruncal ridge defect is seen underneath the aortic and pulmonary valves (filled diamond). A large VSD (arrowhead) is also shown. Note that the muscular layers of the pulmonary trunk (P) and aorta (Ao) are hypoplactic, and thin mesenchyme is observed between the two vessels (arrow). (f) DORV in the single mutant embryo. The conotruncal ridge (filled diamond) is well developed compared with that in e. The arrowhead indicates a VSD.

Copyright

This image is from Yanagisawa H, J Clin Invest 2000 May;105(10):1373-82 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:62261

Associated Alleles

Symbol	Name
Ece1^tm1Reh	endothelin converting enzyme 1; targeted mutation 1, Robert E Hammer
Ece2^tm1Ywa	endothelin converting enzyme 2; targeted mutation 1, Masashi Yanagisawa

Associated Genotypes

Allelic Composition	Genetic Background
Ece1^tm1Reh/Ece1^tm1Reh Ece2^tm1Ywa/Ece2^tm1Ywa	involves: 129S6/SvEvTac * C57BL/6J
Ece1^tm1Reh/Ece1^tm1Reh	involves: 129S6/SvEvTac * C57BL/6J