Phenotype Image Detail

Image

Caption

Electron micrographs of glomerular basal lamina in P66 Col4a3^tm1Jhm/Col4a3^tm1Jhm and control kidneys. Control (A) and Col4a3^tm1Jhm/Col4a3^tm1Jhm (B). The basket-weaving that characterizes glomerular basal lamina (BL) in humans with Alport syndrome is apparent in the mutant. Arrows indicate glomerular BL. RBC, red blood cell. Bar, 0.5 um.

Copyright

This image is from Miner JH, J Cell Biol 1996 Dec;135(5):1403-13, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:37017

Associated Alleles

Symbol	Name
Col4a3^tm1Jhm	collagen, type IV, alpha 3; targeted mutation 1, Jeffrey H Miner

Associated Genotypes

Allelic Composition	Genetic Background
Col4a3^tm1Jhm/Col4a3^tm1Jhm	involves: 129S1/Sv * 129X1/SvJ