Phenotype Image Detail

Image

Caption

Spermatocytes from wild-type (+/+, A and D) and Sycp2^tm1Jw/Sycp2^tm1Jw (-/-, B,C,E and F) mice were stained with anti-SYCP1 serum (green), CREST antiserum (red), and DAPl (blue). A and D: In wild-type pachytene spermatocytes, SYCP1 labels synaptonemal complexes (SCs) that have formed along synapsed homologous chromosomes. CREST antiserum marks 21 foci. B and E: Early mutant spermatocytes contain 40 CREST foci, suggesting that the cohesion of sister chromatids is not affected, at least not in the centromeric regions. SYCP1 is expressed, but apparently not in the form of fibers. C and F: Many short SYCP1 fibers are present in advanced mutant spermatocytes. There are ~34 CREST foci in this nucleus. Note that the CREST foci often exist in pairs.

Copyright

This image is from Yang F, J Cell Biol 2006 May 22;173(4):497-507, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:111287

Associated Alleles

Symbol	Name
Sycp2^tm1Jw	synaptonemal complex protein 2; targeted mutation 1, Jeremy Wang

Associated Genotypes

Allelic Composition	Genetic Background
Sycp2^tm1Jw/Sycp2^tm1Jw	involves: 129S4/SvJae * C57BL/6