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Phenotype Image Detail
Caption Spermatocytes from wild-type (+/+, A and D) and Sycp2tm1Jw/Sycp2tm1Jw (-/-, B,C,E and F) mice were stained with anti-SYCP1 serum (green), CREST antiserum (red), and DAPl (blue). A and D: In wild-type pachytene spermatocytes, SYCP1 labels synaptonemal complexes (SCs) that have formed along synapsed homologous chromosomes. CREST antiserum marks 21 foci. B and E: Early mutant spermatocytes contain 40 CREST foci, suggesting that the cohesion of sister chromatids is not affected, at least not in the centromeric regions. SYCP1 is expressed, but apparently not in the form of fibers. C and F: Many short SYCP1 fibers are present in advanced mutant spermatocytes. There are ~34 CREST foci in this nucleus. Note that the CREST foci often exist in pairs.
Copyright This image is from Yang F, J Cell Biol 2006 May 22;173(4):497-507, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:111287
Symbol Name
Sycp2tm1Jw synaptonemal complex protein 2; targeted mutation 1, Jeremy Wang
Allelic Composition Genetic Background
Sycp2tm1Jw/Sycp2tm1Jw involves: 129S4/SvJae * C57BL/6

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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