Phenotype Image Detail

Image

Caption

Histopathology of liver from Listeria infected Ccr2^tm1Brv/Ccr2^tm1Brv mice. A: Minimal, focal inflammation in a wild type (ccr2^+/+) mouse (arrow). B: Severe, multifocal inflammation and necrosis in a Ccr2^tm1Brv/Ccr2^tm1Brv (ccr2^-/-) mouse (arrows). C: Higher magnification of A. The localized inflammatory focus contains macrophages and neutrophils with necrosis of individual hepatocytes (arrow). D: Higher magnification of B. The lesion is characterized by a central core of coagulative necrosis containing neutrophils and cellular debris. A rim of degenerating and necrotic hepatocytes that contain abundant intracellular Gram-positive bacteria are located at the peripheral margin of the lesion. Insets are sections stained with Gram stain. Bars: A and B, 200um; C and D, 20um.

Copyright

This image is from Kurihara T, J Exp Med 1997 Nov 17;186(10):1757-62, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:111517

Associated Alleles

Symbol	Name
Ccr2^tm1Brv	C-C motif chemokine receptor 2; targeted mutation 1, Rodrigo Bravo

Associated Genotypes

Allelic Composition	Genetic Background
Ccr2^tm1Brv/Ccr2^tm1Brv	involves: 129S1/Sv * ICR