Phenotype Image Detail

Image

Caption

A: Upper panels, Mta2^tm1.1Yzha/Mta2^tm1.1Yzha (KO) mice show skin lesions at eyelid, mouth, nose and neck area as indicated by arrows. Lower panels, hemotoxylene and eosin (H&E) staining of skin sections from wild type (WT) and mutant mice show significant hyperkerotosis (arrow) and epidermal cell hyperplasia (acanthosis) (arrowheads) in mutant mice. B: Upper panels, H&E-stained kidney sections of mutant mice reveal mesangial cell proliferation (arrowhead). Lower panels, mutant mice also show lymphocyte infiltration (arrow) in kidney. C: Mutant mice develop liver inflammation. H&E stained liver sections of mutant mice reveal lymphocyte infiltration (lower panel, arrowhead). Portal veins are indicated by arrows. D: Comparison of the liver enzyme activity levels in serum measured by ELISA. Mutant mice had a significantly increased alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in the serum of mutant mice when compared with wild type mice. Asterisk indicated the difference is statistically significant.

Copyright

This image is from Lu X, J Biol Chem 2008 May 16;283(20):13825-33 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:137101

Associated Alleles

Symbol	Name
Mta2^tm1.1Yzha	metastasis-associated gene family, member 2; targeted mutation 1.1, Yi Zhang

Associated Genotypes

Allelic Composition	Genetic Background
Mta2^tm1.1Yzha/Mta2^tm1.1Yzha	involves: 129S4/SvJae * C57BL/6 * FVB/N