Phenotype Image Detail

Image

Caption

Transmission electron microscopy of wild type (WT, A-C) and Ramp2^tm1Kmca/Ramp2^tm1Kmca (RAMP2^-/-, D-F) lymph sacs at E14.5. In general, the lymphatic endothelial cells (LECs) of mutant mice appeared significantly thinner than those of wild type littermates. Although obvious edema was present in the interstitial space surrounding both the veins and lymph sacs in mutant embryos, endothelial cells could be followed continuously around both vessel types, without obvious breaks or gaps. Other typical ultrastructural features of lymphatic vessels were identified in both wild type and mutant mice including: overlapping contacts (arrowheads), tight junctions (arrows), and anchoring filaments (A). Occasionally necrotic endothelial cells (**) were observed in mutant mice, but the associated tight junctions remained structurally intact. n=2 wild type and 3 mutants. L, lumen. Scale bar: 1um.

Copyright

This image is from Fritz-Six KL, J Clin Invest 2008 Jan;118(1):40-50 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:130930

Associated Alleles

Symbol	Name
Ramp2^tm1Kmca	receptor (calcitonin) activity modifying protein 2; targeted mutation 1, Kathleen Caron

Associated Genotypes

Allelic Composition	Genetic Background
Ramp2^tm1Kmca/Ramp2^tm1Kmca	involves: 129S6/SvEvTac * C57BL/6