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Phenotype Image Detail
Caption Phenotypic series of adrenomedullin signaling-null mice. Genetic deletion of genes responsible for adrenomedullin (AM) signaling results in a phenotypic series of null mice with generalized edema and lethality at mid-gestation. (A) Generalized interstitial edema, without hemorrhage, was observed throughout Calcrltm1Kmca/Calcrltm1Kmca (calcrl-/-) embryos at E12.5. Similar edema was present by E13.5 in Admtm1Unc/Admtm1Unc (AM-/-) embryos (D) and by E14.5 in Ramp2tm1Kmca/Ramp2tm1Kmca (RAMP2-/-) embryos (G). Edema was not observed 1 day before onset, and no viable embryos were recovered 1-2 days after onset. Hematoxylin and eosin stained transverse sections of wild type (+/+) littermates (B,E and H) and Calcrltm1Kmca/Calcrltm1Kmca (C), Admtm1Unc/Admtm1Unc (F), and Ramp2tm1Kmca/Ramp2tm1Kmca (I) embryos at E12.5, E13.5 and E14.5, respectively. Arrowheads indicate interstitial fluid accumulation. Original magnification, A,D and G, x10; B,C,E,F,H and I, x20.
Copyright This image is from Fritz-Six KL, J Clin Invest 2008 Jan;118(1):40-50 and is displayed with the permission of the American Society for Clinical Investigation who owns the Copyright. J:130930
Symbol Name
Admtm1Unc adrenomedullin; targeted mutation 1, University of North Carolina
Calcrltm1Kmca calcitonin receptor-like; targeted mutation 1, Kathleen M Caron
Ramp2tm1Kmca receptor (calcitonin) activity modifying protein 2; targeted mutation 1, Kathleen Caron
Allelic Composition Genetic Background
Calcrltm1Kmca/Calcrltm1Kmca 129S6/SvEvTac-Calcrltm1Kmca
Ramp2tm1Kmca/Ramp2tm1Kmca involves: 129S6/SvEvTac * C57BL/6
Admtm1Unc/Admtm1Unc 129S6/SvEvTac-Admtm1Unc

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