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Caption Three month old mice were used for experiments of high fat feeding. Apoetm1Unc/Apoetm1Unc and Soat1tm1Ishi/Soat1tm1Ishi Apoetm1Unc/Apoetm1Unc mice were fed high fat diet A for 8 weeks; Ldlrtm1Her/Ldlrtm1Her and Soat1tm1Ishi/Soat1tm1Ishi Ldlrtm1Her/Ldlrtm1Her mice were fed high fat diet B for 8 weeks. Apoetm1Unc/Apoetm1Unc (A) and Ldlrtm1Her/Ldlrtm1Her (B) mice had normal epidermal and dermal structure with substantial subcutaneous adipose tissue. No foam cells were observed. In Soat1tm1Ishi/Soat1tm1Ishi Apoetm1Unc/Apoetm1Unc (C and E) and Soat1tm1Ishi/Soat1tm1Ishi Ldlrtm1Her/Ldlrtm1Her (D and F) mice, the dermal layers were extensively infiltrated with fat-laden macrophage (foam cells). Acellular necrotic areas with cholesterol clefts were present. There was a reduced number of hair follicles. Note that subcutaneous adipose tissue was not discernible. High magnification of the dermal layer of Soat1tm1Ishi/Soat1tm1Ishi Apoetm1Unc/Apoetm1Unc (E) and Soat1tm1Ishi/Soat1tm1Ishi Ldlrtm1Her/Ldlrtm1Her (F) mice is shown. Many macrophages exhibited multinucleated giant cell appearance with eosinophilic cytoplasms.
Copyright This image is from Yagyu H, J Biol Chem 2000 Jul 14;275(28):21324-30 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:63468
Symbol Name
Apoetm1Unc apolipoprotein E; targeted mutation 1, University of North Carolina
Ldlrtm1Her low density lipoprotein receptor; targeted mutation 1, Joachim Herz
Soat1tm1Ishi sterol O-acyltransferase 1; targeted mutation 1, Shun Ishibashi
Allelic Composition Genetic Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
involves: 129S7/SvEvBrd * C57BL/6

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