Phenotype Image Detail

Image

Caption

A: Gross appearances of wild type (+/+), Runx2^tm1Ldq/Runx2⁺ (+/-) and Runx2^tm1Ldq/Runx2^tm1Ldq (-/-) newborn mice. The homozygous mice are smaller in size. B and C: Weight and length of wild type and mutant mice. Data are mean +/- S.E. from 13-29 newborn mice. * and # indicate statistical significance at p <0.05 compared with wild type and heterozygous mice, respectively. D: Perinatal mortality of wild type and mutant mice. D0, D1, D3 and D7 (day 0, 1, 3, and 7 after birth); W3 and W6 (week 3 and 6 after birth).

Copyright

This image is from Xiao ZS, J Biol Chem 2004 May 7;279(19):20307-13 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:89822

Associated Alleles

Symbol	Name
Runx2^tm1Ldq	runt related transcription factor 2; targeted mutation 1, L Darryl Quarles

Associated Genotypes

Allelic Composition	Genetic Background
Runx2^tm1Ldq/Runx2^tm1Ldq	involves: C57BL/6J