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Phenotype Image Detail
Image
Caption A: Incidence of lordokyphosis in wild type, Bub3tm1Jvd/Bub3+, Rae1tm1Jvd/Rae1+ and Bub3tm1Jvd/Bub3+ Rae1tm1Jvd/Rae1+ mice. The asterisk indicates that the curve is statistically different from that of wild type mice using a log-rank test. B: Skinned 19 month old Bub3tm1Jvd/Bub3+ Rae1tm1Jvd/Rae1+, 19 month old wild type and 35 month old wild type mice. The double heterozygous mouse and the 35 month old wild type mouse exhibit lordokyphosis (arrowheads) and have little subcutaneous fat (arrows). C: Cross section of gastrocnemius muscles of the mice shown in B. Arrowheads mark degenerated fibers, and arrows mark areas of fibroblast infiltration.
Copyright This image is from Baker DJ, J Cell Biol 2006 Feb 13;172(4):529-40, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:105717
Associated
Alleles
Symbol Name
Bub3tm1Jvd BUB3 mitotic checkpoint protein; targeted mutation 1, Jan M A van Deursen
Rae1tm1Jvd ribonucleic acid export 1; targeted mutation 1, Jan M A van Deursen
Associated
Genotypes
Allelic Composition Genetic Background
Bub3tm1Jvd/Bub3+
Rae1tm1Jvd/Rae1+
Not Specified

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/15/2019
MGI 6.14
The Jackson Laboratory