Phenotype Image Detail

Image

Caption

A: Incidence of lordokyphosis in wild type, Bub3^tm1Jvd/Bub3⁺, Rae1^tm1Jvd/Rae1⁺ and Bub3^tm1Jvd/Bub3⁺ Rae1^tm1Jvd/Rae1⁺ mice. The asterisk indicates that the curve is statistically different from that of wild type mice using a log-rank test. B: Skinned 19 month old Bub3^tm1Jvd/Bub3⁺ Rae1^tm1Jvd/Rae1⁺, 19 month old wild type and 35 month old wild type mice. The double heterozygous mouse and the 35 month old wild type mouse exhibit lordokyphosis (arrowheads) and have little subcutaneous fat (arrows). C: Cross section of gastrocnemius muscles of the mice shown in B. Arrowheads mark degenerated fibers, and arrows mark areas of fibroblast infiltration.

Copyright

This image is from Baker DJ, J Cell Biol 2006 Feb 13;172(4):529-40, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:105717

Associated Alleles

Symbol	Name
Bub3^tm1Jvd	BUB3 mitotic checkpoint protein; targeted mutation 1, Jan M A van Deursen
Rae1^tm1Jvd	ribonucleic acid export 1; targeted mutation 1, Jan M A van Deursen

Associated Genotypes

Allelic Composition	Genetic Background
Bub3^tm1Jvd/Bub3^+ Rae1^tm1Jvd/Rae1^+	Not Specified