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Phenotype Image Detail
Image
Caption A: Radiograph of the whole body of 2 month old wild type (+/+) and Lrp5tm1Kry/Lrp5tm1Kry (-/-) mice showing decreased lucency of the entire mutant skeleton. B: Histological analysis of vertebrae from 2 month old wild type and mutant mice showing low bone mass in the mutant. C: Histological analysis of vertebrae from 2 week old wild type and mutant mice showing a decreased number of trabeculae in the primary spongiosa of mutant mice. D: Mutant mice have a lower bone mass throughout life. Green triangle indicates a significantly lower bone mass in Lrp5tm1Kry/Lrp5+ mice. Asterisks indicate a statistically significant difference between two groups of mice (P<0.05). Error bar represent SD.
Copyright This image is from Kato M, J Cell Biol 2002 Apr 15;157(2):303-14, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:75973
Associated
Alleles
Symbol Name
Lrp5tm1Kry low density lipoprotein receptor-related protein 5; targeted mutation 1, Gerard Karsenty
Associated
Genotypes
Allelic Composition Genetic Background
Lrp5tm1Kry/Lrp5tm1Kry either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory