Phenotype Image Detail

Image

Caption

A: Radiograph of the whole body of 2 month old wild type (+/+) and Lrp5^tm1Kry/Lrp5^tm1Kry (-/-) mice showing decreased lucency of the entire mutant skeleton. B: Histological analysis of vertebrae from 2 month old wild type and mutant mice showing low bone mass in the mutant. C: Histological analysis of vertebrae from 2 week old wild type and mutant mice showing a decreased number of trabeculae in the primary spongiosa of mutant mice. D: Mutant mice have a lower bone mass throughout life. Green triangle indicates a significantly lower bone mass in Lrp5^tm1Kry/Lrp5⁺ mice. Asterisks indicate a statistically significant difference between two groups of mice (P<0.05). Error bar represent SD.

Copyright

This image is from Kato M, J Cell Biol 2002 Apr 15;157(2):303-14, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:75973

Associated Alleles

Symbol	Name
Lrp5^tm1Kry	low density lipoprotein receptor-related protein 5; targeted mutation 1, Gerard Karsenty

Associated Genotypes

Allelic Composition	Genetic Background
Lrp5^tm1Kry/Lrp5^tm1Kry	either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6J)