Phenotype Image Detail

Image

Caption

Matched coronal sections from wild type (+/+, A and C) and Pex2^tm1Plf/Pex2^tm1Plf mice (-/-, B and D) newborn mouse brains spanning medial (A and B) and lateral (C and D) cortical regions, stained with hematoxylin and eosin. The cortical plate (CP) is delimited by arrowheads, and the boundary between the germinative zone (below arrow) and intermediate zone (above arrow) is indicated by an open arrow on the left side (shown in A and B only). The white arrows indicate the boundary between layers VI and V in the developing neocortex. Note the abnormal layering in the cortical plate of the mutant mouse, with loss of distinction between layer boundaries, and the increased density of cells in the intermediate zone. In more lateral cortical regions (C and D), the layer VI/V boundary is easier to discern in the mutant mouse but becomes increasingly blurred as one proceeds medially (third white arrow is absent in D as boundary is not evident; boundary is not evident in B). The subplate (small black arrows in A and C) is obscured in the mutant (B and D) by the increased density of cells in the lower cortical plate and intermediate zone. Scale bar: 100um.

Copyright

This image is from Faust PL, J Cell Biol 1997 Dec 1;139(5):1293-305, and is displayed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported License. J:44975

Associated Alleles

Symbol	Name
Pex2^tm1Plf	peroxisomal biogenesis factor 2; targeted mutation 1, Phyllis L Faust

Associated Genotypes

Allelic Composition	Genetic Background
Pex2^tm1Plf/Pex2^tm1Plf	involves: 129S1/Sv * 129X1/SvJ * C57BL/6