Phenotype Image Detail

Image

Caption

Histological analysis of kidneys. A and B: Light microscopic montages of sections of wild type (Romk^+/+) and Kcnj1^tm1Ges/Kcnj1^tm1Ges (Romk^-/-) kidneys from 8 day old (top) and adult mice (bottom). Renal pelvises are grossly dilated in the mutant mice, and cortex is thinned, relatively more in the adult than in the 8 day old mouse. Scale bar, 3mm. C and D: Light microscopic images of subcortical kidney from wild type (C) and mutant (D) mice. Large lipidic inclusions (arrows) were especially numerous in the cytoplasm of the proximal tubular cells of both 7-9 day and adult mutant mice. Scale bar, 10um. E: Electron micrograph showing the lipid and myelin-like debris often found in the distal tubular lumen of adult mutant mice. Scale bar, 1um. F: Electron micrograph of mitochondria showing increased numbers of native intramitochondrial granules (arrow), a change most prominent in proximal tubular cells of adult mutant mice. Scale bar, 1um.

Copyright

This image is from Lorenz JN, J Biol Chem 2002 Oct 4;277(40):37871-80 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:79354

Associated Alleles

Symbol	Name
Kcnj1^tm1Ges	potassium inwardly-rectifying channel, subfamily J, member 1; targeted mutation 1, Gary E Shull

Associated Genotypes

Allelic Composition	Genetic Background
Kcnj1^tm1Ges/Kcnj1^tm1Ges	involves: 129X1/SvJ * Black Swiss