Phenotype Image Detail

Image

Caption

Light microscopy analyses of vertebral bodies (top), calvarium (center), and nasal section (bottom) were performed on Col1a1^tm1.1Jcm/Col1a1⁺ (Brt1IV) or wild type (WT) mice at 2 months of age. Sections were stained with Masson's Trichrome. The vertebral bodies appeared disorganized and less mineralized in Col1a1^tm1.1Jcm/Col1a1⁺ than wild type. The calvarium is thinner and less mineralized in the mutants. In the maxilla sections, disorganized islands of bone formation are evident in the mutant mice compared with the well organized bone tissue present in the wild type littermates. The pulp cavity of the mutant molars is necrotic with acute inflammation and bacterial infections.

Copyright

This image is from Forlino A, J Biol Chem 1999 Dec 31;274(53):37923-31 and is displayed with the permission of the American Society for Biochemistry and Molecular Biology who owns the Copyright. Full text from JBC. J:59168

Associated Alleles

Symbol	Name
Col1a1^tm1.1Jcm	collagen, type I, alpha 1; targeted mutation 1.1, Joan C Marini

Associated Genotypes

Allelic Composition	Genetic Background
Col1a1^tm1.1Jcm/Col1a1^+	either: (involves: 129X1/SvJ * C3H/HeJ) or (involves: 129X1/SvJ * CD-1)